The South reacted with an elaborate intellectual defense of slavery. J. D. B. De Bow of New Orleans established De Bow's Review in 1846, which quickly grew to become the leading Southern magazine, warning about the dangers of depending on the North economically. De Bow's Review also emerged as the leading voice for secession. The magazine emphasized the South's economic inequality, relating it to the concentration of manufacturing, shipping, banking and international trade in the North. Searching for Biblical passages endorsing slavery and forming economic, sociological, historical and scientific arguments, slavery went from being a "necessary evil" to a "positive good". Dr. John H. Van Evrie's book Negroes and Negro slavery: The First an Inferior Race: The Latter Its Normal Conditionsetting out the arguments the title would suggestwas an attempt to apply scientific support to the Southern arguments in favor of race-based slavery.